Protective Effects of N-Acetyl-L-Cysteine in Human Oligodendrocyte Progenitor Cells and Restoration of Motor Function in Neonatal Rats with Hypoxic-Ischemic Encephalopathy
Identifieur interne : 000572 ( Main/Exploration ); précédent : 000571; suivant : 000573Protective Effects of N-Acetyl-L-Cysteine in Human Oligodendrocyte Progenitor Cells and Restoration of Motor Function in Neonatal Rats with Hypoxic-Ischemic Encephalopathy
Auteurs : Dongsun Park [Corée du Sud] ; Kyungha Shin [Corée du Sud] ; Ehn-Kyoung Choi [Corée du Sud] ; Youngjin Choi [Corée du Sud] ; Ja-Young Jang [Corée du Sud] ; Jihyun Kim [Corée du Sud] ; Heon-Sang Jeong [Corée du Sud] ; Wooryoung Lee [Corée du Sud] ; Yoon-Bok Lee [Corée du Sud] ; Seung Up Kim [Canada] ; Seong Soo Joo [Corée du Sud] ; Yun-Bae Kim [Corée du Sud, Canada]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2015.
Abstract
Url:
DOI: 10.1155/2015/764251
PubMed: 25918547
PubMed Central: 4396975
Affiliations:
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du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Youngjin" sort="Choi, Youngjin" uniqKey="Choi Y" first="Youngjin" last="Choi">Youngjin Choi</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Jang, Ja Young" sort="Jang, Ja Young" uniqKey="Jang J" first="Ja-Young" last="Jang">Ja-Young Jang</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jihyun" sort="Kim, Jihyun" uniqKey="Kim J" first="Jihyun" last="Kim">Jihyun Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Jeong, Heon Sang" sort="Jeong, Heon Sang" uniqKey="Jeong H" first="Heon-Sang" last="Jeong">Heon-Sang Jeong</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Wooryoung" sort="Lee, Wooryoung" uniqKey="Lee W" first="Wooryoung" last="Lee">Wooryoung Lee</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pediatrics, Soonchunhyang University Hospital, Seoul 140-743, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Soonchunhyang University Hospital, Seoul 140-743</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Yoon Bok" sort="Lee, Yoon Bok" uniqKey="Lee Y" first="Yoon-Bok" last="Lee">Yoon-Bok Lee</name><affiliation wicri:level="1"><nlm:aff id="I5">Central Research Institute, Dr. Chung's Food Co. Ltd., Cheongju, Chungbuk 361-782, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Central Research Institute, Dr. Chung's Food Co. Ltd., Cheongju, Chungbuk 361-782</wicri:regionArea><wicri:noRegion>Chungbuk 361-782</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Up" sort="Kim, Seung Up" uniqKey="Kim S" first="Seung Up" last="Kim">Seung Up Kim</name><affiliation wicri:level="1"><nlm:aff id="I6">Division of Neurology, University of British Columbia Hospital, Vancouver, BC, Canada V6T 2B5</nlm:aff><country>Canada</country><wicri:regionArea>Division of Neurology, University of British Columbia Hospital, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Joo, Seong Soo" sort="Joo, Seong Soo" uniqKey="Joo S" first="Seong Soo" last="Joo">Seong Soo Joo</name><affiliation wicri:level="1"><nlm:aff id="I7">Department of Marine Molecular Biotechnology, Gangneung-Wonju National University, Gangneung, Gangwon 210-702, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Marine Molecular Biotechnology, Gangneung-Wonju National University, Gangneung, Gangwon 210-702</wicri:regionArea><wicri:noRegion>Gangwon 210-702</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yun Bae" sort="Kim, Yun Bae" uniqKey="Kim Y" first="Yun-Bae" last="Kim">Yun-Bae Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I6">Division of Neurology, University of British Columbia Hospital, Vancouver, BC, Canada V6T 2B5</nlm:aff><country>Canada</country><wicri:regionArea>Division of Neurology, University of British Columbia Hospital, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25918547</idno><idno type="pmc">4396975</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396975</idno><idno type="RBID">PMC:4396975</idno><idno type="doi">10.1155/2015/764251</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000955</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000955</idno><idno type="wicri:Area/Pmc/Curation">000955</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000955</idno><idno type="wicri:Area/Pmc/Checkpoint">000226</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000226</idno><idno type="wicri:Area/Ncbi/Merge">001B49</idno><idno type="wicri:Area/Ncbi/Curation">001B49</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B49</idno><idno 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362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Ajou University School of Medicine, Suwon, Gyeonggi 443-380, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Ajou University School of Medicine, Suwon, Gyeonggi 443-380</wicri:regionArea><wicri:noRegion>Gyeonggi 443-380</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Kyungha" sort="Shin, Kyungha" uniqKey="Shin K" first="Kyungha" last="Shin">Kyungha Shin</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Ehn Kyoung" sort="Choi, Ehn Kyoung" uniqKey="Choi E" first="Ehn-Kyoung" last="Choi">Ehn-Kyoung Choi</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Youngjin" sort="Choi, Youngjin" uniqKey="Choi Y" first="Youngjin" last="Choi">Youngjin Choi</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Jang, Ja Young" sort="Jang, Ja Young" uniqKey="Jang J" first="Ja-Young" last="Jang">Ja-Young Jang</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jihyun" sort="Kim, Jihyun" uniqKey="Kim J" first="Jihyun" last="Kim">Jihyun Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Jeong, Heon Sang" sort="Jeong, Heon Sang" uniqKey="Jeong H" first="Heon-Sang" last="Jeong">Heon-Sang Jeong</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Wooryoung" sort="Lee, Wooryoung" uniqKey="Lee W" first="Wooryoung" last="Lee">Wooryoung Lee</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Pediatrics, Soonchunhyang University Hospital, Seoul 140-743, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Soonchunhyang University Hospital, Seoul 140-743</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Yoon Bok" sort="Lee, Yoon Bok" uniqKey="Lee Y" first="Yoon-Bok" last="Lee">Yoon-Bok Lee</name><affiliation wicri:level="1"><nlm:aff id="I5">Central Research Institute, Dr. Chung's Food Co. Ltd., Cheongju, Chungbuk 361-782, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Central Research Institute, Dr. Chung's Food Co. Ltd., Cheongju, Chungbuk 361-782</wicri:regionArea><wicri:noRegion>Chungbuk 361-782</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Seung Up" sort="Kim, Seung Up" uniqKey="Kim S" first="Seung Up" last="Kim">Seung Up Kim</name><affiliation wicri:level="1"><nlm:aff id="I6">Division of Neurology, University of British Columbia Hospital, Vancouver, BC, Canada V6T 2B5</nlm:aff><country>Canada</country><wicri:regionArea>Division of Neurology, University of British Columbia Hospital, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Joo, Seong Soo" sort="Joo, Seong Soo" uniqKey="Joo S" first="Seong Soo" last="Joo">Seong Soo Joo</name><affiliation wicri:level="1"><nlm:aff id="I7">Department of Marine Molecular Biotechnology, Gangneung-Wonju National University, Gangneung, Gangwon 210-702, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Marine Molecular Biotechnology, Gangneung-Wonju National University, Gangneung, Gangwon 210-702</wicri:regionArea><wicri:noRegion>Gangwon 210-702</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Yun Bae" sort="Kim, Yun Bae" uniqKey="Kim Y" first="Yun-Bae" last="Kim">Yun-Bae Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763</wicri:regionArea><wicri:noRegion>Chungbuk 362-763</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I6">Division of Neurology, University of British Columbia Hospital, Vancouver, BC, Canada V6T 2B5</nlm:aff><country>Canada</country><wicri:regionArea>Division of Neurology, University of British Columbia Hospital, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Evidence-based Complementary and Alternative Medicine : eCAM</title><idno type="ISSN">1741-427X</idno><idno type="eISSN">1741-4288</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Objective</italic>. Since oligodendrocyte progenitor cells (OPCs) are the target cells of neonatal hypoxic-ischemic encephalopathy (HIE), the present study was aimed at investigating the protective effects of <italic>N</italic>-acetyl-<sc>l</sc>-cysteine (NAC), a well-known antioxidant and precursor of glutathione, in OPCs as well as in neonatal rats. <italic>Methods</italic>. In <italic>in vitro</italic> study, protective effects of NAC on KCN cytotoxicity in F3.Olig2 OPCs were investigated via MTT assay and apoptotic signal analysis. In <italic>in vivo</italic> study, NAC was administered to rats with HIE induced by hypoxia-ischemia surgery at postnatal day 7, and their motor functions and white matter demyelination were analyzed. <italic>Results</italic>. NAC decreased KCN cytotoxicity in F3.Olig2 cells and especially suppressed apoptosis by regulating Bcl2 and p-ERK. Administration of NAC recovered motor functions such as the using ratio of forelimb contralateral to the injured brain, locomotor activity, and rotarod performance of neonatal HIE animals. It was also confirmed that NAC attenuated demyelination in the corpus callosum, a white matter region vulnerable to HIE. <italic>Conclusion</italic>. The results indicate that NAC exerts neuroprotective effects <italic>in vitro</italic> and <italic>in vivo</italic> by preserving OPCs, via regulation of antiapoptotic signaling, and that F3.Olig2 human OPCs could be a good tool for screening of candidates for demyelinating diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Deng, W" uniqKey="Deng W">W. Deng</name></author><author><name sortKey="Pleasure, J" uniqKey="Pleasure J">J. Pleasure</name></author><author><name sortKey="Pleasure, D" uniqKey="Pleasure D">D. 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Raivio</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Park, Dongsun" sort="Park, Dongsun" uniqKey="Park D" first="Dongsun" last="Park">Dongsun Park</name></noRegion><name sortKey="Choi, Ehn Kyoung" sort="Choi, Ehn Kyoung" uniqKey="Choi E" first="Ehn-Kyoung" last="Choi">Ehn-Kyoung Choi</name><name sortKey="Choi, Youngjin" sort="Choi, Youngjin" uniqKey="Choi Y" first="Youngjin" last="Choi">Youngjin Choi</name><name sortKey="Jang, Ja Young" sort="Jang, Ja Young" uniqKey="Jang J" first="Ja-Young" last="Jang">Ja-Young Jang</name><name sortKey="Jeong, Heon Sang" sort="Jeong, Heon Sang" uniqKey="Jeong H" first="Heon-Sang" last="Jeong">Heon-Sang Jeong</name><name sortKey="Joo, Seong Soo" sort="Joo, Seong Soo" uniqKey="Joo S" first="Seong Soo" last="Joo">Seong Soo Joo</name><name sortKey="Kim, Jihyun" sort="Kim, Jihyun" uniqKey="Kim J" first="Jihyun" last="Kim">Jihyun Kim</name><name sortKey="Kim, Yun Bae" sort="Kim, Yun Bae" uniqKey="Kim Y" first="Yun-Bae" last="Kim">Yun-Bae Kim</name><name sortKey="Lee, Wooryoung" sort="Lee, Wooryoung" uniqKey="Lee W" first="Wooryoung" last="Lee">Wooryoung Lee</name><name sortKey="Lee, Yoon Bok" sort="Lee, Yoon Bok" uniqKey="Lee Y" first="Yoon-Bok" last="Lee">Yoon-Bok Lee</name><name sortKey="Park, Dongsun" sort="Park, Dongsun" uniqKey="Park D" first="Dongsun" last="Park">Dongsun Park</name><name sortKey="Shin, Kyungha" sort="Shin, Kyungha" uniqKey="Shin K" first="Kyungha" last="Shin">Kyungha Shin</name></country><country name="Canada"><noRegion><name sortKey="Kim, Seung Up" sort="Kim, Seung Up" uniqKey="Kim S" first="Seung Up" last="Kim">Seung Up Kim</name></noRegion><name sortKey="Kim, Yun Bae" sort="Kim, Yun Bae" uniqKey="Kim Y" first="Yun-Bae" last="Kim">Yun-Bae Kim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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